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Question 1 

A 70-year-old woman has received a diagnosis of chronic myelogenous leukemia (CML) after a clinical investigation sparked by the presence of leukocytosis in her routine blood work. What clinical course should her care provider tell her to expect? 



A. “It’s likely that this will give you chronic fatigue and malaise for the rest of your life, but that will probably be the extent of your symptoms.” 

B. “Unfortunately, your leukemia will likely enter a crisis mode within a few weeks if we don’t treat it immediately.” 

C. “You could remain the chronic stage of CML for several years before it accelerates and culminates in a crisis.” 

D. “You can expect your blood results, fatigue, and susceptibility to infection to gradually worsen over a few years.” 

Question 2 

Following an injury resulting in a small cut from a knife, the first cells to go to the area of the cut would be the 


A. erythrocytes. 

B. basophils. 

C. neutrophils. 

D. albumin. 

Question 3 

Which of the following diagnostic findings is likely to result in the most serious brain insult? 


A. Moderate decrease in brain tissue volume secondary to a brain tumor removal 

B. High intracellular concentration of glutamate 

C. Increased ICP accompanied by hyperventilation 

D. Mean arterial pressure (MAP) that equals intracranial pressure (ICP) 

Question 4 

Which of the following patients would be most likely to be experiencing an increase in renal erythropoietin production? 


A. A 70-year-old woman admitted with dehydration secondary to an overdose of her potassium-wasting diuretic 

B. A 21-year-old man with acute blood loss secondary to a motor vehicle accident 3 hours prior 

C. A 68-year-old man with a long-standing diagnosis of polycythemia vera 

D. A 71-year-old smoker admitted to hospital with exacerbation of his chronic obstructive pulmonary disease (COPD) 

Question 5 

A college student has been experiencing frequent headaches that he describes as throbbing and complaining of difficulty concentrating while studying. Upon cerebral angiography, he is found to have an arteriovenous malformation. Which of the following pathophysiological concepts is likely responsible for his symptoms? 


A. Localized ischemia with areas of necrosis noted on CT angiography 

B. High pressure and local hemorrhage of the venous system 

C. Hydrocephalus and protein in the cerebral spinal fluid 

D. Increased tissue perfusion at the site of the malformation 

Question 6 

A group of nursing students were studying for their pathophysiology exam by quizzing each other about disorders of WBCs and lymphoid tissue. When asked what the first chromosomal abnormality that identified cancer was, one student correctly answered Answers: 

A. interleukin cells. 

B. Philadelphia. 

C. PSA. 

D. BRCA-1. 

Question 7 

A 47-year-old woman was diagnosed with amyotrophic lateral sclerosis 3 years ago and has experienced a progressive onset and severity of complications. She has been admitted to a palliative care unit due to her poor prognosis? What assessments and interventions should the nursing staff of the unit prioritize in their care? 


A. Regular pain assessment and administration of opioid analgesics as needed 

B. Cardiac monitoring and administration of inotropic medications 

C. Assessment and documentation of cognitive changes, including confusion and restlessness 

D. Assessment of swallowing ability and respiratory status 

Question 8 

A 53-year-old man presents with inability to concentrate, itching in his fingers and toes, elevated blood pressure, and unexplained weight loss. He is diagnosed with primary polycythemia. What will be the primary goal of his treatment? 


A. To increase the amount of oxygen distributed by his red blood cells 

B. To reduce the viscosity of his blood 

C. To reduce the mean size of his red cells 

D. To control his hypertension 

Question 9 

During a late night study session, a pathophysiology student reaches out to turn the page of her textbook. Which of the following components of her nervous system contains the highest level of control of her arm and hand action? 


A. Thalamus 

B. Cerebellum 

C. Frontal lobe 

D. Basal ganglia 

Question 10 

The family members of an elderly patient are wondering why his “blood counts” are not rising after his last GI bleed. They state, “He has always bounced back after one of these episodes, but this time it isn’t happening. Do you know why?” The nurse will respond based on which of the following pathophysiological principles? 


A. “Don’t worry about it. We can always give him more blood.” 

B. “Due to stress, the red blood cells of older adults are not replaced as promptly as younger people.” 

C. “Everything slows down when you get older. You just have to wait and see what happens.” 

D. “The doctor may start looking for another cause of his anemia, maybe cancer of the bone.” 

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